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Napa Valley - USA
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San Diego is a coastal Southern California city located in the southwestern corner of the continental United States. In 2006, the city's population was estimated to be 1,256,951. It is the second largest city in California and the eighth largest city in the United States, by population. It is the county seat of San Diego County. and is the economic center of the San Diego–Carlsbad–San Marcos metropolitan area, the 17th-largest in the United States with a population of 2.9 million as of 2006, and the 21st-largest metropolitan area in the Americas when including Tijuana (See San Diego-Tijuana Metro.). San Diego County lies just north of the Mexican border—sharing a border with Tijuana—and lies south of Orange County. It is home to miles of beaches, a mild Mediterranean climate and 16 military facilities hosting the United States Navy, the United States Coast Guard and the United States Marine Corps. The presence of the University of California, San Diego (UCSD) with the affiliated UCSD Medical Center promotes research in biotechnology. San Diego's economy is largely composed of agriculture, biotechnology/biosciences, computer sciences, electronics manufacturing, defense-related manufacturing, financial and business services, ship-repair and construction, software development, telecommunications, and tourism The area has long been inhabited by the Kumeyaay people. The first European to visit the region was Portuguese-born explorer Juan Rodrigues Cabrillo sailing under the Spanish Flag, (1499 - 1543), who sailed his flagship San Salvador from Navidad, New Spain. Cabrillo claimed the bay for the Spanish Empire and named the site San Miguel. In November of 1602, Sebastián Vizcaíno was sent to map the California coast. Arriving on his flagship San Diego, Vizcaíno surveyed the harbor and what are now Mission Bay and Point Loma and named the area for the Catholic Saint Didacus, a Spaniard more commonly known as San Diego. On November 12, 1602, the first Christian religious service of record in Alta California was conducted by Fray Antonio de la Ascensión, a member of Vizcaíno's expedition, to celebrate the feast day of San Diego. In 1769, Gaspar de Portolà established the Presidio of San Diego (a military post) overlooking Old Town. Around the same time, Mission San Diego de Alcalá was founded by Franciscan friars under Father Junípero Serra. By 1797, the mission boasted the largest native population in Alta California, with over 1,400 neophytes living in and around the mission proper. After New Spain won its independence from the Spanish Empire in 1823, Mission San Diego de Alcalá's fortunes declined in the 1830s after the decree of secularization was enacted, as was the case with all of the missions under the control of Mexico. In 1847 San Diego was a destination of the 2,000-mile (3,200 km) march of the Mormon Battalion which built the city's first courthouse with brick. After the Battle of San Pasqual, the end of the Mexican-American War, and the gold rush of 1848, San Diego was designated the seat of the newly-established San Diego County and was incorporated as a city in 1850. In the years before World War I, the Industrial Workers of the World labor union conducted a free speech fight in San Diego, arousing a brutal response (see San Diego Free Speech Fight.)

The three largest sectors of San Diego's economy are defense, manufacturing, and tourism respectively. Several areas of San Diego (in particular La Jolla and surrounding Sorrento Valley areas) are home to offices and research facilities for numerous biotechnology companies. Major biotechnology companies like Neurocrine Biosciences and Nventa Biopharmaceuticals are headquartered in San Diego, while many biotech and pharmaceutical companies, such as BD Biosciences, Biogen Idec, Integrated DNA Technologies, Merck, Pfizer, Élan, Genzyme, Cytovance, Celgene and Vertex, have offices or research facilities in San Diego. There are also several non-profit biotech institutes, such as the Salk Institute for Biological Studies, the Scripps Research Institute and the Burnham Institute. The presence of University of California, San Diego and other research institutions helped fuel biotechnology growth. In June 2004, San Diego was ranked the top biotech cluster in the U.S. by the Milken Institute. San Diego is home to companies that develop wireless cellular technology. Qualcomm Incorporated was founded and is headquartered in San Diego; Qualcomm is the largest private-sector technology employer (excluding hospitals) in San Diego County. The largest software company in San Diego (according to the San Diego Business Journal) is security software company Websense Inc.

With the automobile being the primary means of transportation for over 80 percent of its residents, San Diego is served by an extensive network of freeways and highways. This includes Interstates 5, which runs south to Tijuana and runs north to the Canadian border through Orange County, Los Angeles, Sacramento, Portland, and Seattle; I-8, which runs east to Imperial County and Arizona; I-15, which runs north to the Canadian border through Riverside County and Salt Lake City; and I-805, which splits from I-5 at Sorrento Valley and rejoins I-5 near the Mexican border. Notable state highways are SR 94, which connects downtown with I-805, I-15 and east county; SR 163, which connects downtown with the northeast part of the city, intersects I-805 and merges with I-15 at Miramar; SR 52, which connects La Jolla with east county through Santee and SR 125; SR 56, which connects I-5 with I-15 through Carmel Valley and Rancho Peñasquitos; and SR 75 (San Diego-Coronado Bridge), which spans San Diego Bay. Several regional transportation projects have been undertaken in recent years to deal with congestion on San Diego freeways. This includes expansion of Interstates 5 and 805 around "The Merge," a rush-hour spot where the two freeways meet. Also, an expansion of Interstate 15 through the North County is underway with the addition of high-occupancy-vehicle (HOV) "managed lanes". There is also a tollway (The South Bay Expressway) connecting SR 54 and Otay Mesa, near the Mexican border. According to a 2007 assessment, only 37 percent of streets in San Diego are in acceptable driving condition and the proposed budget falls $84.6 million short of bringing the city's streets to an acceptable level. Less than three percent of San Diego residents use mass transit. San Diego is served by the trolley, bus, Coaster, and Amtrak. The trolley (system map) primarily serves downtown and surrounding urban communities, Mission Valley, east county and coastal south bay. A planned Mid-Coast line will operate from Old Town to University City along the 5 Freeway. There are also plans for a Silver Line to expand trolley service downtown. The Amtrak and Coaster trains currently run along the coastline and connect San Diego with Los Angeles, Orange County, Riverside, San Bernardino, and Ventura via MetroLink. There are three Amtrak stations in San Diego, in Sorrento Valley, Old Town, and Union Station (downtown). The bus is available along almost all major routes, however a large number of bus stops are concentrated in central San Diego. Typical wait times vary from 15 to 30 minutes, depending on the location and route. Trolleys arrive every 7 to 30 minutes (depending on time of day and which trolley line is used). Ferries are also available every half hour crossing San Diego Bay to Coronado.

San Diego International Airport, also known as Lindbergh International Airport or Lindbergh Field, is the primary commercial airport serving San Diego. It is the busiest single-runway airport in the United States, serving over 17 million passengers every year, and is located on San Diego Bay three miles from downtown. It offered scheduled flights to the rest of the United States, Mexico, Hawaii, and Canada. It serves as a focus city for Southwest Airlines and ExpressJet Airlines. Other airports include Brown Field Municipal Airport (Brown Field) and Montgomery Field. Aeroméxico provides a shuttle service from San Diego to General Abelardo L. Rodríguez International Airport in Tijuana, Baja California, Mexico. There has been debate regarding the placement of a new international airport. While the San Diego Airport Authority has endorsed the current site of the Miramar Marine Corps Air Station, the military said it has no intention of relinquishing that site. A vote on the issue took place on November 7, 2006 against Proposition A, in which voters rejected the proposal to move the airport to Miramar. The military has rejected the proposals for a dual-use airport because the area around Miramar has already been set aside as safety corridors for military aircraft accidents. A shared commercial/military airport would force military aircraft to fly outside of those safety corridors.
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